Plot: Ron Woodroof (Matthew McConaughey) gets AIDS in 1985 when the first generation of anti-AIDS drugs had just come out. He can't get into a drug trial, so he buys anti-viral drugs in Mexico, and opens up a "Buyer's Club" in Dallas to skirt drug importation laws. As he distributes drugs he meets the cross-dressing, fellow HIV-positive Rayon (Jared Leto) who helps him distribute to the gay community. Dr Eve (Jennifer Garner) at a Dallas Hospital is his doctor, and who provides a window to the medical establishment. [imdb] [photos]
Jared Leto's Rayon begins as an entry point into Gay culture, and some comic relief; later we see the sad backstory and some emotional energy returns. Jared Leto is fun to watch the whole time, and he is a highlight.
Jennifer Garner has a less interesting role; as a hospital doctor she has no backstory, and needs to introduce medical facts to the story. This makes her character dry. I am glad she doesn't get romanic with Ron at the end: there are too many doctor-patent ethic problems in the movies.